题目：Proposed Center for the Physics of Cancer Progression
时间：2014年7月10日（周四）上午10点
地点：光电工程学院多功能厅
报告人：Robert H. Austin教授（美国科学院院士，普林斯顿大学）
主持人：屈军乐
教授
摘要：
As a physicist, my mission is to bring to the clinic a quantitative,
physics-based analysis of the likely progression of cancer ecology from the
pre-cancerous state to the proliferating state to metastasis, studied over
multiple time and spatial scales. The analysis of this progression is based both
on the sampled time and spatial heterogenous genetic state of individual tumor
cancer cells and more globally using a game theoretic analysis of the
immune-stromal-tumor cell ecology dynamics. The physics basis behind this
analysis comes from in vitro experiments which recapitulate the game-theoretic
dynamics of 2 and 3 dimensional complex ecologies, ecologies which have been
designed to allow analysis at a deep and quantitive level of the interaction
between the 3 main players in the development of a metastatic cancer: the immune
cells, the stromal cells, and the cancer cells, with full recognition that all
three players are inhomogenous phenotypically, and
genetically.
简历：
Robert H.
Austin received his B.A. in Physics from Hope College in Holland MI and his
Ph.D. in Physics from the University of Illinois Champaign-Urbana in 1976. He
did a post-doc at the Max Planck Institute for Biophysical Chemistry from
1976-1979 and has been at Princeton University in the Department from Physics
from 1979 to the present, achieving the rank of Professor of Physics in
1989.
He is a Fellow of the American Physical Society, a Fellow of the
American Association for the Advancement of Science, and was elected a member of
the National Academy of Sciences USA. He has served as a President of the
Division of Biological Physics of the American Physical Society, and is the
present Chair of the U.S. Liaison Committee of the International Union of Pure
and Applied Physics. He has served as the biological physics editor for Physical
Review Letters, serves on numerous review panels for NIH, NSF, the Burroughs
Wellcome Fund and NIST, and is the Editor of the Virtual Journal of Biological
Physics. He won the 2005 Edgar Lilienfeld Prize of the American Physical
Society.
The Robert H. Austin Research Group in Biophysics is a research group based in the physics department of Princeton
University which probes the biological limits of evolving organisms under
stress.
The group focuses primarily on the use of microarrays and
nanotechnology to further our physical understanding of biological processes,
such as the dynamics of cells when subjected to stress. They ultimately want to
understand, and possible guide, the evolution of microrganisms by culturing them
inside custom-made micro-environments.
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