杨志刚

发表于 2015-05-26 18:30

杨志刚，博士, 讲师。2004年毕业于中国地质大学（武汉）材料科学与化学工程学院, 获工学学士学位；2011年就读于大连理工大学精细化工国家重点实验室，获得工学博士学位。2011年9月至2014年10月在韩国高丽大学理学馆从事博士后研究工作（研究教授）；2015年5月入职深圳大学光电工程学院。主要研究兴趣包括: 用于荧光超分辨成像、荧光寿命成像及生物靶向输送与可控释放。近五年内，在国内外学术期刊上已经发表论文15篇，申请专利3项。 

联系方式 
    邮箱：zhgyang_hp@hotmail.com  

研究方向 
 可用于细胞内超分辨荧光成像与荧光寿命成像的功能材料的设计与合成，生物体系内药物的靶向输送、定位成像与可控释放材料的研究。 

科研项目 
[1] 国家自然科学基金青年基金项目：基于肿瘤缺氧调控的药物靶向输送系统及其荧光成像的研究（21406125），2015.1-2017.12，负责人 

论文目录
[1]Kwak, Jong Hwan†; Yang, Zhigang†; Yoon, Byungkwon; He, Yanxia; Uhm, Soojin; Shin, Hyeon-Cheol; Lee, Bong Ho; Yoo, Yung Choon; Lee, Kyung Bok*; Han, Seung-Yun*;  and Kim, Jong Seung*; Blood-brain Barrier-permeable Fluorone-labeled Dieckols Acting as Neuronal ER Stress Signaling Inhibitors; Biomaterials, 2015, Accepted. († Co-first author) 
[2]Yang, Zhigang; He, Yanxia; Lee, Jae Hong;Chae, Weon-Sik; Ren, Wen Xiu; Lee, Joung Hae; Kang, Chulhun *and Kim, Jong Seung *; A Nile Red/BODIPY-based bimodal probe sensitive to changes in the micropolarity and microviscosity of the endoplasmic reticulum; Chemical Communications, 2014, 50, 11672-11675.
[3]Kwak, Jong Hwan; He, Yanxia; Yoon, Byungkwon; Koo, Seyoung; Yang, Zhigang; Kang, Eun Ju; Lee, Bong Ho; Han, Seung-Yun; Yoo, Yung Choon*; Lee, Kyung Bok* and Kim, Jong Seung*; Synthesis of rhodamine-labelled dieckol: Its unique intracellular localization and potent anti-inflammatory Activity; Chemical Communications, 2014,50, 13045-13048.
[4]Yang,Zhigang; Cao, Jianfang; He, Yanxia; Yang, Jung Ho; Kim, Taeyoung; Peng, Xiaojun * and Kim, Jong Seung *; Marco-/micro-environment-sensitive chemosensing and biological imaging; Chemical Society Reviews, 2014,43, 4563-4601.
[5]Yang, Zhigang; Lee, Jae Hong; Jeon, Hyun Mi; Han, Ji Hye; Park, Nayoung; He, Yanxia; Lee, Hyunseung; Hong, Kwan Soo*; Kang, Chulhun* and Kim, Jong Seung*; Marco-/micro-environment-sensitive chemosensing and biological imaging; Jounal of the American Chemical Society 2013, 135, 11657-11662.
[6]Yang, Zhigang; He, Yanxia; Lee, Jae-Hong; Park, Nayoung; Suh, Myungkoo; Chae, Weon-Sik; Cao, Jianfang; Peng,Xiaojun; Jung, Hyosung; Kang, Chulhun*and Kim, Jong Seung*; A self-calibrating bipartite viscosity sensor for mitochondria; Jounal of the American Chemical Society  2013, 135, 9181-9185. 
[7]Lee, Min Hee; Yang, Zhigang; Lim, Choon Woo; Lee, Yun Hak; Dongbang, Sun; Kang, Chulhun* and Kim, Jong Seung*; Disulfide cleavage triggered chemosensors and their biological applications; Chemical Reviews 2013,113, 5071-5109.
[8]Peng, Xiaojun*; Yang, Zhigang; Wang, Jingyun; Fan, Jiangli; He, Yanxia; Song, Fengling; Wang, Bingshuai; Sun, Shiguo; Qu, Junle; Qi, Jing; Yan, Meng; Fluorescence Ratiometry and Fluorescence Lifetime Imaging: Using a Single Molecular Sensor for Dual Mode Imaging of Cellular Viscosity; Jounal of the American Chemical Society 2011, 133(17), 6626-6635.
[9]Li, Zhiyong; Sun, Shiguo*; Yang, Zhigang; Zhang, Si; Zhang, Hua; Hu, Mingming; Cao, Jianfang; Wang, Jingyun; Liu, Fengyu; Song, Fengling; Fan, Jiangli; Peng, Xiaojun*; The Use of a Near-Infrared RNA Fluorescent Probe with a Large Stokes Shift for Imaging Living Cells Assisted by the macrocyclic molecule CB7; Biomaterials 2013, 34, 6473-6481.
[10]Liu, Fei; Wu, Tong; Cao, Jianfang; Cui, Shuang; Yang, Zhigang; Qiang, Xinxin; Sun, Shiguo; Song, Fengling; Fan, Jiangli; Wang, Jingyun* and Peng, Xiaojun*;  Ratiometric Detection of Viscosity Using a Two-Photon Fluorescent Sensor; Chemistry- A European Journal 2013, 19(15),1548-1553. Chen, Gengwen; Song, Fengling*; Wang, Jingyun; Yang, Zhigang; Sun, Shiguo; Fan, Jiangli; Qiang, Xinxin; Wang, Xu; Dou, Bairui and Peng, Xiaojun*; FRET spectral unmixing: a ratiometric fl uorescent nanoprobe for hypochlorite; Chemical Communications 2012, 48, 2949-2951.
[11]Ren, Wen Xiu; Pradhan, Tuhin; Yang, Zhigang; Cao, Qian-Yong and Kim, Jong Seung∗; Rapid responsive palladium sensor under mild condition; Sensors and Actuators B 2012, 171-172, 1277-1282.
[12]Sun, Shiguo*; He, Yanxia; Yang, Zhigang; Pang, Yi; Liu, Fengyu; Fan, Jiangli; Sun, Licheng; Peng, Xiaojun; Synthesis and DNA photocleavage study of Ru(bpy)3 2+-(CH2)n-MV2+ complexes; Dalton Transactions, 2010, 39(18), 4411-4416.
[13]杨志刚，和艳霞，戴彬，窦柏蕊，王静云，彭孝军*，中位醛基取代Cy5 的光谱性能及作为粘度荧光探针的研究; 化学学报，2011, 69(4), 445-451.
[14]王炳帅，王丽，吴彤，杨志刚，彭孝军*，苯乙烯类菁染料pH探针的合成与活细胞成，高等化学学报，2010, 31(6), 1148-1151.
[15]Han, Feng; Bao, Yuhui; Yang, Zhigang; Fyles, Thomas M; Zhao, Jianzhang*; Peng, Xiaojun; Fan, Jiangli; Wu, Yunkou; Sun, Shiguo; Simple Bisthiocarbonohydrazones as Sensitive, Selective, Colorimetric, and Switch-On Fluorescent Chemosensors for Fluoride Anions; Chemistry- A European Journal 2007, 13(10), 2880-2892.

专利目录
[1]彭孝军,*杨志刚，和艳霞，王静云，樊江莉，孙世国，宋锋玲，一类五甲川菁染料制备方法及其应用，中国专利号：ZL 2011 1 033941.1 
[2]彭孝军,*杨志刚，宋锋玲，和艳霞，孙世国，樊江莉，一类共轭链上β-位氮取代五甲川菁类荧光染料，中国专利号：ZL 2010 1 0010134.3
[3] Peng, Xiaojun;* Yang, Zhigang; Song, Fengling; He, Yanxia; Sun, Shiguo; Fan, Jiangli; Pentamethine Cyanine Fluorescent Dyes with N-substituting at β-position of Conjugated Chain, US patent, 美国专利号：US8735601 B2