深圳大学光电工程学院博士后招聘; 深圳大学“柔性可拉伸电子”方向招聘青年教师及博士后; 深圳大学光电子器件与系统教育部重点实验室拟招聘博士后研究人员1-2名; 深圳大学光电工程学院“光子技术与器件”研究方向博士后招聘; 深圳大学光电子器件与系统教育部重点实验室,国家“青年千人”获得者、深圳大学特聘教授王科拟招聘博士后研究人员1-2名;

学术报告四十三_Fingerprinting Single Cell Metabolism by

发表于 2017-10-11 15:04


报告题目:Fingerprinting Single Cell Metabolism by Hyperspectral Stimulated Raman Scattering Microscopy

报告时间:201792016:15

报告地点:北区光电工程学院多功能厅

报告人:王平 教授(华中科技大学)

报告摘要:Direct molecular imaging and characterization of cancerous tissues without tedious pathology or fluorescent labelling have been long pursued. However, the current available label-free imaging modalities either lack enough sensitivity to detect low concentrated bio-molecules in cells, or fail to provide imaging contrast with desired specificity. Here, we developed hyperspectral stimulated Raman scattering (SRS) imaging(1-3) method to investigate cancerous tissues from patients(4). We studied chemical constitutions of mouse brain with high spatial resolution by obtained Raman spectra in only 140 nm sized pixels. Our study illustrated the great promise of hyperspectral SRS as a powerful metabolic imaging tool in both biological and clinical applications.

References

1.   D. L. Zhang et al., Quantitative Vibrational Imaging by Hyperspectral Stimulated Raman Scattering Microscopy and Multivariate Curve Resolution Analysis. Anal. Chem. 85, 98-106 (2013).

2.   P. Wang et al., Label-Free Quantitative Imaging of Cholesterol in Intact Tissues by Hyperspectral Stimulated Raman Scattering Microscopy. Angewandte Chemie-International Edition 52, 13042-13046 (2013).

3.   P. Wang et al., Imaging Lipid Metabolism in Live Caenorhabditis elegans Using Fingerprint Vibrations. Angew Chem Int Ed Engl 53, 11787-11792 (2014).

4.   S. Yue et al., Cholesteryl ester accumulation induced by PTEN loss and PI3K/AKT activation underlies human prostate cancer aggressiveness. Cell Metab. 19, 393-406 (2014).

报告人简介:Professor Ping Wang received his B.Sc. from Department of Physics, Wuhan University in 2002 and Ph.D. from Wuhan Institute of Physics and Mathematics, CAS in 2007. He began his postdoctoral research from 2008 at Purdue University. After he got the national award of ’Chinese Youth 1000 Program’ in 2015, he started independent research career on Stimulated Raman scattering microscopy as a Professor at Wuhan National laboratory for optoelectronics, Huazhong University of Science and Technology.

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