深圳大学光电工程学院博士后招聘; 深圳大学“柔性可拉伸电子”方向招聘青年教师及博士后; 深圳大学光电子器件与系统教育部重点实验室拟招聘博士后研究人员1-2名; 深圳大学光电工程学院“光子技术与器件”研究方向博士后招聘; 深圳大学光电子器件与系统教育部重点实验室,国家“青年千人”获得者、深圳大学特聘教授王科拟招聘博士后研究人员1-2名;

学术报告三十二_Laser-ablative synthesis of functional nanomaterials

发表于 2017-09-04 17:14


题目:Laser-ablative synthesis of functional nanomaterials for biomedical applications

时间:201784日(周五)上午10

地点:南校区光电工程学院1212会议室

报告人:Andrei V. KabashinAix-Marseille University

摘要:The presentation will overview our on-going activities on “non-chemical” laser ablative synthesis of novel classes of biocompatible colloidal nanomaterials (Si, Au, Ge, AuPd, TixOy, ZnO etc) and their testing in biomedical tasks. Our original approach is based on ultra-short (fs) laser ablation from a solid target [1] or already formed water-suspended colloids [2] to achieve an efficient control of size characteristics of “bare” ligand-free nanomaterials, or fabricate nanomaterials coated by functional biopolymers (dextran, PEG) [3] to minimize immune response of biological systems. Our recent tests were focused on the synthesis and applications of Si-based nanomaterials.  We showed that these nanomaterials demonstrate excellent cell uptake, while the composition of protein corona covering nanoparticles promises a good transport of nanomaterials in vivo [4]. We also found that a systemic administration of such nanomaterials in small animal model is not accompanied by any toxicity effects, while Si nanoparticles are rapidly sequestered by the liver and spleen, then further biodegraded and directly eliminated with the urine [5,6]. Laser-synthesized nanomaterials are now actively tested in cancer diagnostics and therapy (theranostics) tasks [7]. In particular, we showed that laser-synthesized nanomaterials can be used as photoluminescent contrast agents to image tumor area [8] or sensitizers of local heating in radiofrequency radiation-based hyperthermia [9]. Finally, we showed that bare metal nanoparticles synthesized by laser ablation can provide an order of magnitude better response in glucose oxidation tasks, which promises their use as elecrocatalysts in bioimplantable therapeutic devices [10].  

[1] A.V. Kabashin, M. Meunier, J. Appl. Phys., 94, 7941 (2003)

[2] K. Maximova, A. I. Aristov, M. Sentis, A. V. Kabashin, Nanotechnology, 26, 065601 (2015)

[3] A.V. Kabashin et al, J. Phys. Chem B, 107, 4527 (2003)

[4] F. Correard et al, Int. J. Nanomedicine, 9, 5415 (2014)

[5] T. Baati et al, Sci. Rep. 6, 25400 (2016)

[6] A. Al-Kattan et al, J. Mater. Chem. B, 4, 7852 (2016).

[7] A. V. Kabashin, V. Yu. Timoshenko, Nanomedicine, 11, 2247 (2016).

[8] K. P. Tamarov et al, Sci. Rep., 4, 7034 (2014)

[9] M. B. Gongalsky et al, Sci. Rep., 6, 24732 (2016)

[10] S. Hebié et al, ACS Catalysis, 5, 6489  (2015)

报告人简介:Prof. A. V. Kabashin is one of world leading experts in plasmonics/metamaterial-based biosensing and laser-ablative nanofabrication. He obtained his MS Degree in 1990 from Moscow Institute of Physics and technology (MIPT) and his Ph.D. degree in 1994 from A.M. Prokhorov General Physics Institute, Moscow, Russia. From 1999 to 2008 he worked as Research Professor of the University of Montreal, Canada. Since 2009 he holds a Research Director position of the French National Center of Scientific Research (CNRS) in Aix-Marseille University, Marseille, France. He is also a Scientific Director of the Institute of Engineering Physics for Biomedicine (PhysBio) and the Head of International Laboratory “Bionanophotonics” of the National Nuclear Research University (MEPhI), Moscow, Russia. Finally, he holds an Adjunct Professorship in the Institute of Lasers, Photonics and Biophotonics in State University of New York at Buffalo (USA) and an Associate Professorship the University of Sherbrooke (Canada)

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