发表于 2017-09-04 17:14
题目：Laser-ablative synthesis of functional nanomaterials for biomedical applications
报告人：Andrei V. Kabashin（Aix-Marseille University）
摘要：The presentation will overview our on-going activities on “non-chemical” laser ablative synthesis of novel classes of biocompatible colloidal nanomaterials (Si, Au, Ge, AuPd, TixOy, ZnO etc) and their testing in biomedical tasks. Our original approach is based on ultra-short (fs) laser ablation from a solid target  or already formed water-suspended colloids  to achieve an efficient control of size characteristics of “bare” ligand-free nanomaterials, or fabricate nanomaterials coated by functional biopolymers (dextran, PEG)  to minimize immune response of biological systems. Our recent tests were focused on the synthesis and applications of Si-based nanomaterials. We showed that these nanomaterials demonstrate excellent cell uptake, while the composition of protein corona covering nanoparticles promises a good transport of nanomaterials in vivo . We also found that a systemic administration of such nanomaterials in small animal model is not accompanied by any toxicity effects, while Si nanoparticles are rapidly sequestered by the liver and spleen, then further biodegraded and directly eliminated with the urine [5,6]. Laser-synthesized nanomaterials are now actively tested in cancer diagnostics and therapy (theranostics) tasks . In particular, we showed that laser-synthesized nanomaterials can be used as photoluminescent contrast agents to image tumor area  or sensitizers of local heating in radiofrequency radiation-based hyperthermia . Finally, we showed that bare metal nanoparticles synthesized by laser ablation can provide an order of magnitude better response in glucose oxidation tasks, which promises their use as elecrocatalysts in bioimplantable therapeutic devices .
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 F. Correard et al, Int. J. Nanomedicine, 9, 5415 (2014)
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 A. V. Kabashin, V. Yu. Timoshenko, Nanomedicine, 11, 2247 (2016).
 K. P. Tamarov et al, Sci. Rep., 4, 7034 (2014)
 M. B. Gongalsky et al, Sci. Rep., 6, 24732 (2016)
 S. Hebié et al, ACS Catalysis, 5, 6489 (2015)
报告人简介：Prof. A. V. Kabashin is one of world leading experts in plasmonics/metamaterial-based biosensing and laser-ablative nanofabrication. He obtained his MS Degree in 1990 from Moscow Institute of Physics and technology (MIPT) and his Ph.D. degree in 1994 from A.M. Prokhorov General Physics Institute, Moscow, Russia. From 1999 to 2008 he worked as Research Professor of the University of Montreal, Canada. Since 2009 he holds a Research Director position of the French National Center of Scientific Research (CNRS) in Aix-Marseille University, Marseille, France. He is also a Scientific Director of the Institute of Engineering Physics for Biomedicine (PhysBio) and the Head of International Laboratory “Bionanophotonics” of the National Nuclear Research University (MEPhI), Moscow, Russia. Finally, he holds an Adjunct Professorship in the Institute of Lasers, Photonics and Biophotonics in State University of New York at Buffalo (USA) and an Associate Professorship the University of Sherbrooke (Canada)
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